Genex Resveratrol 1500mg 3 Pack -Max Strength – Antioxidant Supplement Extract | Trans-Resveratrol Works Well with NMN Nicotinamide Mononucleotide Made in a GMP Facility 90-Day Supply

$59.85

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Price: $59.85
(as of Oct 07,2020 13:57:14 UTC – Details)

Product Description

HEALTHY AGING & THE IMPORTANCE OF NAD+

Scientists have discovered that as we get older, our NAD+ levels steadily decrease, and by the time we get to our late 70s and 80s, our NAD+ levels appear to be very much lower, than those of younger people. Polyphenols like Resveratrol which help to support the NAD+ pool, used in combination with NAD+ precursors is quickly emerging as a popular strategy to promote healthy aging or healthspan.

Why is Resveratrol so important to NAD+?

Resveratrol is a Sirtuin Activator and an NAD+ Booster. It is the most powerful naturally occurring STAC, compounds that can directly activate our longevity genes known as SIRTUINS. Sirtuins are gene silencers that turn genes on or off like switches. This ensures that only the right switches are turned on, keeping cells healthy and working properly. These are just a tiny fraction of the many positive benefits that scientists have discovered so far but perhaps one of the most overlooked findings about Resveratrol is its ability to allosterically modify the NMNAT enzyme. This is important because all cells need this enzyme in order to create and recycle the very important NAD+ molecule. Resveratrol speeds up this process making it more efficient. This makes resveratrol a dual-action anti-aging powerhouse, because it can activate sirtuins and boost NAD+ levels at the same time. Combining Resveratrol with an NAD+ precursor makes for the perfect anti-aging combo!

Is there a link between falling NAD+ levels & aging?

Well, the science is starting to clearly show a definite correlation between falling NAD levels and an age-related decline in health & wellness. In 2013 Harvard researchers published a study, where they were able to actually reverse some parts of aging by treating old mice with NMN (an NAD+ precursor). After treating the mice for ten days, key biometric markers that were measured resembled those of much younger mice. For the first time, we have real evidence that some aspects of aging may be reversible. In 2017 the same research team published a follow-up article. It demonstrated a new understanding of how NAD+ is not only used to repair damaged DNA but how it also stimulates the repair process. It does this by blocking another protein called DBC1 that interferes with the PARP-1 DNA Repair enzyme. This is a key finding because an accumulation of DNA damage has long been understood as a part of the aging process.

NAD (Nicotinamide Adenine Dinucleotide) is a molecule found in all living cells and is essential for life. It exists in two forms, NAD+ the oxidized form and NADH the reduced form. NAD is responsible for many critical cell functions, such as energy metabolism, mitochondrial function, calcium hemostasis, and gene expression.

What is Resveratrol? Resveratrol is a polyphenol produced by plants as a protection mechanism in response to stresses such as sun radiation damage or a fungal attack. Remarkably, by consuming Resveratrol we can also gain many health-promoting benefits, such as:

Cardiovascular support
Brain health
Immune Functionality
Healthy metabolism
Support NAD levels

Also Resveratrol has anti-inflammatory properties that also help to support NAD+ levels. It targets cytokine induced expression of the greatest NAD+ destroyer, the ectoenzyme called CD38. Resveratrol promotes healthy brain and cognitive function by supporting the integrity of the blood-brain-barrier. The blood-brain-barrier weakens with age and this allows some damaging proteins to enter the brain. A 2017 study showed that Resveratrol significantly slows this process. Resveratrol has the rare ability to cross the blood-brain-barrier and deliver its anti-aging antioxidant benefits. The research and understanding into NAD+ metabolomics continues, but what the science has clearly highlighted thus far, is the importance of supporting and maintaining our NAD+ levels. Resveratrol can help to reduce the expression of NAD+ consumer CD38, boost NAD+ levels and directly activate Sirtuins.

What is Mitochondria? The Mitochondrion (plural mitochondria) is regularly called the powerhouse of the cell. This is because most of the chemical energy needed to sustain life is produced inside the mitochondria by a process called oxidative phosphorylation that produces ATP. The mitochondria are NAD dependent for functional mechanics and for coordination with the cell Nucleus. Without the NADH to NAD+ cycle, cells cannot produce energy, and as the NAD pool declines with age, so does our energy levels.

Why Trans- Resveratrol with BioPerine?

Resveratrol has poor bioavailability, which makes it difficult for us to get the benefits of eating it or supplementing it. Black pepper extract or piperine (BioPerine) has been shown to boost the performance of Resveratrol tremendously. For this reason why we combined Trans-Resveratrol with BioPerine to get the maximum effect.

Is there a correlation between falling NAD levels and aging?

Scientists have discovered that as we get older, our NAD+ levels steadily decrease, and by the time we get to our late 70s &80s, our NAD+ levels appear to be much lower, than those of younger people. The science is starting to clearly show a definite correlation between falling NAD levels and an age-related decline in health & wellness. In 2013 Harvard researchers published a study, where they were able to reverse some parts of aging by treating old mice with NMN, a direct NAD+ precursor supplement. After ten days of treatment, key biometrics markers measured resembled those of much younger mice. For the first time, we have real evidence that some aspects of aging may be reversible. In 2017 the same team published a follow-up article. It demonstrated a new understanding of how NAD+ is not only used to repair damaged DNA but how it also stimulates the repair process. It does this by blocking another protein called DBC1 that interferes with the PARP-1 DNA Repair enzyme.

The Power of Three! Why NMN, Resveratrol & Berberine is a Powerful Combination

So far, at least three major longevity pathways have been identified by researchers. The SIRTUIN gene regulators that silence genes and repair DNA, the AMPK activated pathway, and the mTOR pathway which influences cell division and growth.

The power of three, positively promote these synergistic pathways to better our chances of a favorable outcome when supplemented together. NMN is excellent, as it provides the fuel for Sirtuins and the substrate for DNA repair. However, Resveratrol is also very important as it independently activates Sirtuins and to a lesser extent, inhibits mTOR activity. Finally, Berberine which is one of the better studied natural plant extracts is a good AMPK activator that stimulates mitochondrial biogenesis and offers other benefits by turning on genes similar to those turned on by exercise.

NMN Nicotinamide Mononucleotide NAD+ Booster

NMN is an entirely natural compound found in our bodies. Various food sources also contain this compound in minuscule amounts. Edamame which has one of the higher contents, only show less than 1.9mg/100g. NMN is a direct and potent NAD+ supplement. Mice given an oral supplement of NMN showed increased liver NAD+ levels in just 10 minutes and showed an increase in muscle tissue by 30 minutes.

Increased NAD+ levels stimulate energy, DNA repair, and SIRTUIN activity. SIRTUINS are the longevity-genes shown to be active during caloric restriction and life-extension in many animal models.

Resveratrol with BioPerine

At Genex, we chose to use an all-natural and organic source of Resveratrol that was extracted from Japanese knotweed (also known as Polygonum cuspidatum root) which contains 50% Trans-Resveratrol. Resveratrol has several remarkable properties that help to support good health. Most commonly, Resveratrol is known as the longevity supplement found in red wine and generally as an effective antioxidant. Resveratrol is also the most potent naturally occurring direct SIRTUIN activating compound.

Berberine AMPK Activator

AMPK Activator Berberine is a natural plant-based compound found in several different plants, including Barberry (Berberis vulgaris). Berberine is known as a direct AMPK activator. The AMPK pathway, in short, is one of the things that happens during exercise, the expression of a set of genes known to promote longevity. Both human and animal studies show Berberine may have the potential to support healthy blood sugar levels, already in the normal range. Berberine may also help support healthy cholesterol, gut, brain, heart, and inflammation. Berberine is a general health and wellness supplement that has been used as a traditional herb for thousands of years.

Sirtuin Activator – Longevity Support

Blood Sugar Support

Antioxodent

Promotes Healthy Immune Funtion

AMPK Activator

GMO Free

Glutten Free

OUR ADVANTAGE: We understand your money is hard earned and important. It is, for this reason, we add a small amount of BioPerine to our Resveratrol product to help with absorption. Studies show that BioPerine can increase absorption rates up to 1500%. This helps ensure that you are getting the maximum benefits from the dose you take!
A SIRTUIN Activator – That promotes NAD+ biosynthesis. Srtuins are the gene regulators that silence genes and keep cells working normally, ultimately promoting good health.
Supports Healthy Cardiovascular System

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